Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.41 |
| ▸ | FLT1 | P17948 | 10/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | FLT4 | P35916 | 3/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746378 | 1.00 | KDR (0.41) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL30746407 | 0.89 | KDR (0.41) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL26985004 | 0.89 | KDR (0.41) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL26984976 | 0.83 | NUDT1 (0.38) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL30746381 | 0.83 | NUDT1 (0.38) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL26984914 | 0.82 | SLC6A2 (0.39) | — | |
| SCHEMBL30746596 | 0.82 | SLC6A2 (0.39) | — | |
| SCHEMBL30746544 | 0.81 | NUDT1 (0.36) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL26985280 | 0.81 | NUDT1 (0.36) | KDRFLT1FGFR1NUDT1EGFR | |
| SCHEMBL26984868 | 0.80 | NUDT1 (0.42) | KDRFLT1FGFR1NUDT1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001845-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS INC (US) | 2026-01-01 | — | — | US | disclosed |
| US-20250288571-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. | 2025-09-18 | — | — | US | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001845-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | MAPK6, MAPK3, MAPK1 | KDR 818/4885FLT1 3167/4885FGFR1 350/4885 |
| US-20250288571-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | BRAF, MAP3K1, MAP3K5 | KDR 911/4885FLT1 1164/4885FGFR1 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.