SCHEMBL26985173

SCHEMBL26985173

CNC(=O)c1cc2sc3nc(-c4ccc(C5CCN(C(=O)OC(C)(C)C)C5)cc4F)cn3c2cc1OC

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 5/20 0.45
▸ JAK3 P52333 4/20 0.39
▸ JAK2 O60674 3/20 0.39
▸ PTK2 Q05397 3/20 0.39
▸ GPR119 Q8TDV5 3/20 0.38
▸ USP30 Q70CQ3 2/20 0.38
▸ LCK P06239 1/20 0.38
▸ BTK Q06187 1/20 0.38
▸ ALK Q9UM73 1/20 0.37
▸ TRPV3 Q8NET8 1/20 0.37
▸ PDE4A P27815 1/20 0.37
▸ PDE4C Q08493 1/20 0.37
▸ PDE4D Q08499 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ CCNT1 O60563 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30727281 1.00 PDE4B (0.45) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL31327740 1.00 PDE4B (0.45) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL26985423 0.93 PDE4B (0.46) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL30727293 0.93 PDE4B (0.46) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL31327730 0.92 PDE4B (0.47) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL30727270 0.92 PDE4B (0.47) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL26985441 0.92 PDE4B (0.47) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL30727304 0.92 PDE4B (0.48) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL26985159 0.92 PDE4B (0.48) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL31327697 0.91 PDE4B (0.42) PDE4BJAK3PTK2USP30LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250353862-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-11-20 — — US disclosed
WO-2024010761-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250353862-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 PDE4B 3361/4885JAK3 2191/4885JAK2 1671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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