SCHEMBL30727281

SCHEMBL30727281

CNC(=O)c1cc2sc3nc(-c4ccc(C5CCN(C(=O)OC(C)(C)C)C5)cc4F)cn3c2cc1OC

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 5/20 0.45
▸ JAK3 P52333 4/20 0.39
▸ JAK2 O60674 3/20 0.39
▸ PTK2 Q05397 3/20 0.39
▸ GPR119 Q8TDV5 3/20 0.38
▸ USP30 Q70CQ3 2/20 0.38
▸ LCK P06239 1/20 0.38
▸ BTK Q06187 1/20 0.38
▸ ALK Q9UM73 1/20 0.37
▸ TRPV3 Q8NET8 1/20 0.37
▸ PDE4A P27815 1/20 0.37
▸ PDE4C Q08493 1/20 0.37
▸ PDE4D Q08499 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ CCNT1 O60563 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26985173 1.00 PDE4B (0.45) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL31327740 1.00 PDE4B (0.45) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL26985423 0.93 PDE4B (0.46) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL30727293 0.93 PDE4B (0.46) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL31327730 0.92 PDE4B (0.47) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL30727270 0.92 PDE4B (0.47) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL26985441 0.92 PDE4B (0.47) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL30727304 0.92 PDE4B (0.48) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL26985159 0.92 PDE4B (0.48) PDE4BJAK3JAK2PTK2GPR119
SCHEMBL31327697 0.91 PDE4B (0.42) PDE4BJAK3PTK2USP30LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4547671-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2025-05-07 — — EP disclosed
WO-2024010761-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 — — WO disclosed
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