Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | GRM6 | O15303 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nbqx SCHEMBL29412437 | 0.99 | MAPT (0.74) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| Nbqx SCHEMBL220464 | 0.99 | MAPT (0.74) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| Nbqx SCHEMBL30728067 | 0.98 | MAPT (0.73) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| Nbqx SCHEMBL2230845 | 0.91 | MAPT (0.65) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| SCHEMBL9341166 | 0.89 | KMT2A (0.61) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| SCHEMBL28120662 | 0.84 | KMT2A (0.61) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| Nbqx SCHEMBL20501770 | 0.84 | MAPT (1.00) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| SCHEMBL9670143 | 0.83 | KDM4E (0.52) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| Nbqx SCHEMBL29985796 | 0.83 | MAPT (0.98) | MAPTKDM4EKMT2AHPGDHSD17B10 | |
| SCHEMBL5044934 | 0.80 | MAPT (0.52) | MAPTKDM4EKMT2AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024009280-A1 | INTEGRATED STRESS RESPONSE INHIBITORS AND METHODS OF USING THE SAME | BAYLOR COLLEGE OF MEDICINE (US) | 2024-01-11 | — | — | WO | disclosed |