Nbqx

Nbqx

SCHEMBL220464

NS(=O)(=O)c1cccc2c1c([N+](=O)[O-])cc1nc(O)c(O)nc12

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.74
KDM4E B2RXH2 4/20 0.74
KMT2A Q03164 4/20 0.74
HPGD P15428 2/20 0.74
HSD17B10 Q99714 2/20 0.74
TP53 P04637 1/20 0.74
CYP1A2 P05177 1/20 0.74
PKM P14618 1/20 0.74
BLM P54132 1/20 0.74
MEN1 O00255 3/20 0.50
ALDH1A1 P00352 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
GRM6 O15303 1/20 0.50
GLA P06280 1/20 0.50
THRB P10828 1/20 0.50
ALOX15 P16050 1/20 0.50
CYP2C19 P33261 1/20 0.50
GRIK1 P39086 1/20 0.50
GRIA1 P42261 1/20 0.50
GRIA2 P42262 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nbqx SCHEMBL29412437 1.00 MAPT (0.74) MAPTKDM4EKMT2AHPGDHSD17B10
Nbqx SCHEMBL26985644 0.99 MAPT (0.73) MAPTKDM4EKMT2AHPGDHSD17B10
Nbqx SCHEMBL30728067 0.99 MAPT (0.73) MAPTKDM4EKMT2AHPGDHSD17B10
Nbqx SCHEMBL2230845 0.92 MAPT (0.65) MAPTKDM4EKMT2AHPGDHSD17B10
SCHEMBL9341166 0.90 KMT2A (0.61) MAPTKDM4EKMT2AHPGDHSD17B10
SCHEMBL28120662 0.85 KMT2A (0.61) MAPTKDM4EKMT2AHPGDHSD17B10
Nbqx SCHEMBL20501770 0.85 MAPT (1.00) MAPTKDM4EKMT2AHPGDHSD17B10
SCHEMBL9670143 0.84 KDM4E (0.52) MAPTKDM4EKMT2AHPGDHSD17B10
Nbqx SCHEMBL29985796 0.84 MAPT (0.98) MAPTKDM4EKMT2AHPGDHSD17B10
SCHEMBL5044934 0.81 MAPT (0.52) MAPTKDM4EKMT2AHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 755 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240132511-A1 TREATMENTS OF PRADER-WILLI SYNDROME NEUREN PHARMACEUTICALS LIMITED (NZ) 2024-04-25 US claimed
US-20230301994-A9 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME NEUREN PHARMACEUTICALS LIMITED (NZ) 2023-09-28 US claimed
US-20220387426-A1 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME NEUREN PHARMACEUTICALS LTD (NZ) 2022-12-08 US claimed
US-20220354808-A1 GLYCOLIC ACID PROTECTS AGAINST ISCHEMIC INSULTS PAN MONTOJO FRANCISCO (DE) 2022-11-10 US claimed
EP-3377055-B1 GLYCOLIC ACID PROTECTS AGAINST ISCHEMIC INSULTS PAN MONTOJO FRANCISCO (DE) 2021-10-13 EP claimed
EP-3024463-B1 NEUROPROTECTIVE BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING AUTISM SPECTRUM DISORDERS AND NEURODEVELOPMENTAL DISORDERS NEUREN PHARMACEUTICALS LTD (NZ) 2020-03-25 EP claimed
US-20180325849-A1 GLYCOLIC ACID PROTECTS AGAINST ISCHEMIC INSULTS PAN MONTOJO FRANCISCO (DE) 2018-11-15 US claimed
EP-3377055-A1 GLYCOLIC ACID PROTECTS AGAINST ISCHEMIC INSULTS Pan-Montojo, Francisco (DE) 2018-09-26 EP claimed
US-20180140601-A1 Neuroprotective Bicyclic Compounds and Methods for Their Use in Treating Autism Spectrum Disorders and Neurodevelopmental Disorders NEUREN PHARMACEUTICALS LIMITED (NZ) 2018-05-24 US claimed
US-9867823-B2 Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders NEUREN PHARMACEUTICALS LIMITED (NZ) 2018-01-16 US claimed
EP-1100504-A2 PHARMACEUTICAL COMPOSITIONS AND THEIR USES FOR TREATMENT OF DEMYELINATING DISORDERS Eisai Co., Ltd. (JP) 2001-05-23 EP claimed
US-6172043-B1 GENETIC ENGINEERED POLYPEPTIDE MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2001-01-09 US claimed
WO-2000071102-A2 INHIBITORS OF PROTON-GATED CATION CHANNELS AND THEIR USE IN THE TREATMENT OF ISCHAEMIC DISORDERS NEUROSEARCH A/S (DK) 2000-11-30 WO claimed
EP-1015013-A1 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-07-05 EP claimed
EP-1002535-A1 New use of glutamate antagonists for the treatment of cancer Ikonomidou, Hrissanthi (DE) 2000-05-24 EP claimed
WO-2000024395-A1 NEW USE OF GLUTAMATE ANTAGONISTS FOR THE TREATMENT OF CANCER IKONOMIDOU HRISSANTHI (DE) 2000-05-04 WO claimed
WO-2000001376-A2 PHARMACEUTICAL COMPOSITIONS AND THEIR USES FOR TREATMENT OF DEMYELINATING DISORDERS EISAI CO., LTD (JP) 2000-01-13 WO claimed
WO-1998030229-A1 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY β-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1998-07-16 WO claimed
WO-1994022446-A1 PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF NEURONAL CELL DEATH NOVO NORDISK A/S (DK) 1994-10-13 WO claimed
US-4889855-A ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS A/S FERROSAN (DK) 1989-12-26 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132511-A1 TREATMENTS OF PRADER-WILLI SYNDROME COMT, HSD17B3, HSD3B1 MAPT 3291/4885KDM4E 3101/4885KMT2A 901/4885
US-20180140601-A1 Neuroprotective Bicyclic Compounds and Methods for Their Use in Treating Autism Spectrum Disorders and Neurodevelopmental Disorders GRIN2C, GRIN2D, GRIN2A MAPT 762/4885KDM4E 2626/4885KMT2A 1533/4885
US-20230301994-A9 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME QPCT, GRIA2, GGPS1 MAPT 309/4885KDM4E 2713/4885KMT2A 500/4885
US-20220387426-A1 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME QPCT, GRIA2, GGPS1 MAPT 309/4885KDM4E 2713/4885KMT2A 500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.