Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068248 | 1.00 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL2700983 | 0.92 | CARM1 (0.37) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL1068377 | 0.92 | CARM1 (0.37) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL1069541 | 0.91 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPT | |
| SCHEMBL2703301 | 0.91 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPT | |
| SCHEMBL1067287 | 0.91 | FDFT1 (0.35) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL1067285 | 0.91 | FDFT1 (0.35) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL2700348 | 0.88 | GNRHR (0.35) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL1066291 | 0.88 | GNRHR (0.35) | ALDH1A1SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL2700658 | 0.88 | NPSR1 (0.38) | ALDH1A1SMN1; SMN2NPSR1MAPTANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274297-B1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2012-05-09 | — | — | EP | disclosed |
| US-7741327-B2 | Pyrrolidinone glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | GCKR, GCK, PDK2 | ALDH1A1 1129/4885SMN1; SMN2 2392/4885LMNA 3936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.