Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25382828 | 0.89 | AKR1C3 (0.48) | EPHX2AKR1C3AKR1C2ACACBS1PR1 | |
| SCHEMBL30593610 | 0.89 | AKR1C3 (0.48) | EPHX2AKR1C3AKR1C2ACACBS1PR1 | |
| SCHEMBL27014383 | 0.87 | PPARG (0.44) | EPHX2SRD5A2PPARGPPARAAKR1C3 | |
| SCHEMBL27014290 | 0.86 | SRD5A2 (0.40) | EPHX2SRD5A2AKR1C3AKR1C2ACACB | |
| SCHEMBL27099623 | 0.86 | PPARG (0.41) | EPHX2SRD5A2PPARGPPARAAKR1C3 | |
| SCHEMBL27014616 | 0.79 | SRD5A2 (0.37) | EPHX2SRD5A2PPARGPPARAAKR1C3 | |
| SCHEMBL27014588 | 0.79 | SRD5A2 (0.37) | EPHX2SRD5A2PPARGPPARAAKR1C3 | |
| SCHEMBL27099617 | 0.77 | KDM1A (0.36) | SRD5A2PPARGPPARA | |
| SCHEMBL27014624 | 0.77 | SRD5A2 (0.34) | EPHX2SRD5A2PPARGPPARAAKR1C3 | |
| SCHEMBL30593616 | 0.76 | AKR1C3 (0.48) | AKR1C3AKR1C2ACACBAKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912679-B2 | Aryl alkynamide derivatives | ASTELLAS PHARMA, INC. (JP) | 2024-02-27 | — | — | US | disclosed |
| US-11912679-B2 | Aryl alkynamide derivatives | ASTELLAS PHARMA, INC. (JP) | 2024-02-27 | — | — | US | disclosed |
| US-20240018113-A1 | ARYL ALKYNAMIDE DERIVATIVES | ASTELLAS PHARMA, INC. (JP) | 2024-01-18 | — | — | US | disclosed |
| US-20240018113-A1 | ARYL ALKYNAMIDE DERIVATIVES | ASTELLAS PHARMA, INC. (JP) | 2024-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018113-A1 | ARYL ALKYNAMIDE DERIVATIVES | STING1, IRF3, TBK1 | EPHX2 3355/4885SRD5A2 4735/4885PPARG 4665/4885 |
| US-11912679-B2 | Aryl alkynamide derivatives | STING1, IRF3, TBK1 | EPHX2 3355/4885SRD5A2 4735/4885PPARG 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.