Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297608 | 0.95 | GNAI3 (0.44) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL4290518 | 0.87 | MEN1 (0.44) | GNAI3GNAI1GNAO1ALDH1A1MEN1 | |
| SCHEMBL9415769 | 0.83 | GNAI3 (0.56) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL16756662 | 0.83 | GNAI3 (0.56) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL10337915 | 0.83 | GNAI3 (0.56) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL9415827 | 0.83 | GNAI3 (0.56) | GNAI3GNAI1GNAO1L3MBTL1MEN1 | |
| SCHEMBL30983344 | 0.81 | GLA (0.59) | GNAI3GNAI1GNAO1L3MBTL1ALDH1A1 | |
| SCHEMBL24476755 | 0.81 | GAA (0.41) | GNAI3GNAI1GNAO1MEN1KMT2A | |
| SCHEMBL4440119 | 0.81 | KMT2A (0.62) | L3MBTL1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL12282009 | 0.81 | KDM4E (0.49) | GNAI3GNAI1GNAO1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287161-B1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | OTSUKA PHARMA CO LTD (JP) | 2012-05-09 | — | — | EP | disclosed |
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | disclosed |
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |