Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | PRKCA | P17252 | 5/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DGKA | P23743 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28517054 | 1.00 | MAPT (0.68) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10531401 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10529607 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10598164 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10529619 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL11675125 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10529616 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10529700 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10528901 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE | |
| SCHEMBL10531368 | 0.85 | LMNA (0.61) | MAPTMAPK1LMNAPRKCAPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016130501-A1 | AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2016-08-18 | — | — | WO | disclosed |
| EP-2448938-A1 | PYRIMIDINONES AS PI3K INHIBITORS | Incyte Corporation (US) | 2012-05-09 | — | — | EP | disclosed |