Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2705049 | 0.91 | DPP4 (0.39) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL2703644 | 0.90 | DPP4 (0.39) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL8269278 | 0.88 | DPP4 (0.42) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL2706200 | 0.86 | TP53 (0.40) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL8446881 | 0.86 | TRPC3 (0.38) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL2701632 | 0.84 | GPR119 (0.39) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL2701634 | 0.84 | GPR119 (0.39) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL4408122 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL2702832 | 0.79 | DPP4 (0.44) | DPP4CYP3A4DPP8DPP9CYP2C19 | |
| SCHEMBL2705111 | 0.79 | DPP4 (0.51) | DPP4CYP3A4DPP8DPP9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888589-B1 | PYRROLOPYRIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-1888589-B1 | PYRROLOPYRIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |