Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 5/20 | 0.40 |
| ▸ | PRKACA | P17612 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 5/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.40 |
| ▸ | CDC7 | O00311 | 4/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29958152 | 1.00 | CYP3A4 (0.43) | CYP3A4CYP2C19CLK4PIM1PRKACA | |
| SCHEMBL17920909 | 0.77 | F2 (0.41) | CYP3A4CYP2C19JAK2KLKB1MAP4K1 | |
| SCHEMBL29957948 | 0.76 | ABL1 (0.44) | CYP3A4CYP2C19CLK4KDRFGFR1 | |
| SCHEMBL27033591 | 0.76 | ABL1 (0.44) | CYP3A4CYP2C19CLK4KDRFGFR1 | |
| SCHEMBL7443703 | 0.72 | PRMT5 (0.48) | JAK2KLKB1MAP4K1PRMT5WDR77 | |
| SCHEMBL29481417 | 0.72 | PRMT5 (0.48) | JAK2KLKB1MAP4K1PRMT5WDR77 | |
| SCHEMBL23452595 | 0.71 | KLKB1 (0.50) | KLKB1MAP4K1ITK | |
| Hydrochloric Acid SCHEMBL7213801 | 0.71 | PRMT5 (0.47) | JAK2KLKB1MAP4K1PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL29485586 | 0.71 | PRMT5 (0.47) | JAK2KLKB1MAP4K1PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL16881193 | 0.71 | PRMT5 (0.47) | JAK2KLKB1MAP4K1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382482-A1 | PLASMA KALLIKREIN INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2024-11-21 | — | — | US | disclosed |
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240382482-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | CYP3A4 1770/4885CYP2C19 1479/4885CLK4 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.