Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 9/20 | 0.40 |
| ▸ | ITK | Q08881 | 9/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443703 | 1.00 | PRMT5 (0.48) | PRMT5WDR77SGK1KLKB1MAP4K1 | |
| Hydrochloric Acid SCHEMBL29485586 | 0.98 | PRMT5 (0.47) | PRMT5WDR77SGK1KLKB1MAP4K1 | |
| Hydrochloric Acid SCHEMBL7213801 | 0.98 | PRMT5 (0.47) | PRMT5WDR77SGK1KLKB1MAP4K1 | |
| Hydrochloric Acid SCHEMBL16881193 | 0.98 | PRMT5 (0.47) | PRMT5WDR77SGK1KLKB1MAP4K1 | |
| SCHEMBL17920909 | 0.81 | F2 (0.41) | PRMT5WDR77KLKB1MAP4K1BTK | |
| SCHEMBL29958243 | 0.80 | BTK (0.44) | PRMT5WDR77KLKB1MAP4K1BTK | |
| SCHEMBL27033870 | 0.80 | BTK (0.44) | PRMT5WDR77KLKB1MAP4K1BTK | |
| SCHEMBL7220924 | 0.79 | PRMT5 (0.48) | PRMT5WDR77SGK1BTKIGF1R | |
| SCHEMBL23491251 | 0.78 | KLKB1 (0.48) | PRMT5WDR77KLKB1MAP4K1BTK | |
| SCHEMBL29958524 | 0.78 | BTK (0.44) | PRMT5WDR77SGK1KLKB1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4626891-A1 | FUSED PYRIMIDINES AS MASP-2 INHIBITORS | Omeros Corporation (US) | 2025-10-08 | — | — | EP | disclosed |
| CN-119350433-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-112867706-B | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118373875-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-07-23 | — | — | CN | disclosed |
| WO-2024118840-A1 | FUSED PYRIMIDINES AS MASP-2 INHIBITORS | OMEROS CORPORATION (US) | 2024-06-06 | — | — | WO | disclosed |
| CN-118043316-A | Factor XIIa inhibitors | 卢纳克治疗有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2022248883-A1 | FACTOR XIIA INHIBITORS | LUNAC THERAPEUTICS LTD (GB) | 2022-12-01 | — | — | WO | disclosed |
| CN-114269431-A | Enzyme inhibitors | 卡尔维斯塔制药有限公司 | 2022-04-01 | — | — | CN | disclosed |