⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977837 | 0.85 | — | — | |
| SCHEMBL26978104 | 0.81 | — | — | |
| SCHEMBL30559681 | 0.78 | TRPV4 (0.34) | — | |
| SCHEMBL26978025 | 0.78 | TRPV4 (0.34) | — | |
| SCHEMBL7020692 | 0.72 | TRPV4 (0.41) | — | |
| SCHEMBL31221676 | 0.71 | IDO1 (0.39) | — | |
| SCHEMBL27040617 | 0.69 | CDC7 (0.32) | — | |
| SCHEMBL357264 | 0.69 | DHODH (0.39) | — | |
| SCHEMBL31507111 | 0.69 | CDC7 (0.32) | — | |
| SCHEMBL17368 | 0.67 | TRPV4 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744661-A2 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-05-20 | — | — | EP | disclosed |
| EP-4298092-B1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-11-26 | — | — | EP | disclosed |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-25 | — | — | US | disclosed |