Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.48 |
| ▸ | GABRE | P78334 | 2/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.48 |
| ▸ | FADS1 | O60427 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354194 | 0.92 | RECQL (0.57) | RECQLGAAGABRPGABRDGABRA1 | |
| SCHEMBL2704988 | 0.85 | RECQL (0.50) | RECQLFADS1POLBKMT2ARORB | |
| SCHEMBL2705789 | 0.80 | RECQL (0.62) | RECQLFADS1KMT2A | |
| SCHEMBL29858361 | 0.80 | RECQL (0.71) | RECQLFADS1KMT2A | |
| SCHEMBL29515875 | 0.80 | RECQL (0.71) | RECQLFADS1KMT2A | |
| SCHEMBL333224 | 0.80 | RECQL (0.71) | RECQLFADS1KMT2A | |
| SCHEMBL23927132 | 0.79 | GAA (0.49) | GAACDK4CDK2CDK1MEN1 | |
| SCHEMBL30202190 | 0.79 | GAA (0.49) | GAACDK4CDK2CDK1MEN1 | |
| SCHEMBL2876974 | 0.78 | GAA (0.58) | GAACDK4CDK2POLBMEN1 | |
| SCHEMBL9540049 | 0.78 | RECQL (0.79) | RECQLFADS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083906-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARM INC (US) | 2024-03-14 | — | — | US | disclosed |
| US-20220041605-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2022-02-10 | — | — | US | disclosed |
| US-11014928-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200247810-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2020-08-06 | — | — | US | disclosed |
| US-10414770-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180134716-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| US-9765078-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| EP-2719698-B1 | Methods for preparing aurora kinase inhibitors | MILLENNIUM PHARM INC (US) | 2016-10-05 | — | — | EP | disclosed |
| EP-2746285-B1 | Process for the preparation of aurora kinase inhibitors | MILLENNIUM PHARM INC (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20160185782-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2016-06-30 | — | — | US | disclosed |
| US-20090299060-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-7572784-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1771450-B9 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE | MILLENNIUM PHARM INC (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1905773-A2 | Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-02 | — | — | EP | disclosed |
| EP-1771450-B1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE | MILLENNIUM PHARM INC (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20070185087-A1 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| CN-101014603-A | Compounds and methods for inhibiting mitosis by inhibiting aurora kinase | MILLENNIUM PHARM INC (US) | 2007-08-08 | — | — | CN | disclosed |
| EP-1771450-A2 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2005111039-A2 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050256102-A1 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247810-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20050256102-A1 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20070185087-A1 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-10414770-B2 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20180134716-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-11014928-B2 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20090299060-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20220041605-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20160185782-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
| US-20240083906-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | RECQL 414/4885GAA 2051/4885GABRP 4819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.