Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699415 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL549102 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL2699036 | 0.94 | MAPT (0.40) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL550881 | 0.94 | MAPT (0.40) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL551112 | 0.94 | MAPT (0.40) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL2699038 | 0.94 | MAPT (0.40) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL550880 | 0.94 | MAPT (0.40) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL551111 | 0.94 | MAPT (0.40) | KDM4EALDH1A1HPGDHSD17B10S1PR1 | |
| SCHEMBL3701831 | 0.92 | S1PR1 (0.39) | S1PR1HSD11B1CYP2C9NPY2R | |
| SCHEMBL2700830 | 0.92 | S1PR1 (0.39) | S1PR1HSD11B1CYP2C9NPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2450351-A1 | Lactam compounds and their use as pharmaceuticals | Incyte Corporation (US) | 2012-05-09 | — | — | EP | disclosed |