Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699038 | 1.00 | MAPT (0.40) | MAPTKDM4EALDH1A1ALKS1PR1 | |
| SCHEMBL550881 | 1.00 | MAPT (0.40) | MAPTKDM4EALDH1A1ALKS1PR1 | |
| SCHEMBL2699036 | 1.00 | MAPT (0.40) | MAPTKDM4EALDH1A1ALKS1PR1 | |
| SCHEMBL551112 | 1.00 | MAPT (0.40) | MAPTKDM4EALDH1A1ALKS1PR1 | |
| SCHEMBL550880 | 1.00 | MAPT (0.40) | MAPTKDM4EALDH1A1ALKS1PR1 | |
| SCHEMBL2699415 | 0.94 | KDM4E (0.43) | MAPTKDM4EALDH1A1S1PR1CYP2C9 | |
| SCHEMBL549102 | 0.94 | KDM4E (0.43) | MAPTKDM4EALDH1A1S1PR1CYP2C9 | |
| SCHEMBL2704571 | 0.94 | KDM4E (0.43) | MAPTKDM4EALDH1A1S1PR1CYP2C9 | |
| SCHEMBL2697960 | 0.92 | ALK (0.39) | MAPTALKS1PR1CYP2C9EML4 | |
| SCHEMBL5930343 | 0.92 | ALK (0.39) | MAPTALKS1PR1CYP2C9EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |