Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707585 | 0.75 | LMNA (0.50) | LMNAF2TDP1ALDH1A1TSHR | |
| SCHEMBL14877345 | 0.75 | LMNA (0.59) | LMNAF2TDP1ALDH1A1TSHR | |
| Benzoyl Peroxide SCHEMBL2929886 | 0.71 | LMNA (1.00) | LMNAF2TDP1ALDH1A1TSHR | |
| Benzoyl Peroxide SCHEMBL63 | 0.71 | LMNA (1.00) | LMNAF2TDP1ALDH1A1TSHR | |
| Benzoyl Peroxide SCHEMBL3467853 | 0.71 | LMNA (1.00) | LMNAF2TDP1ALDH1A1TSHR | |
| Benzoyl Peroxide SCHEMBL5312311 | 0.71 | LMNA (1.00) | LMNAF2TDP1ALDH1A1TSHR | |
| Benzoyl Peroxide SCHEMBL9407293 | 0.71 | LMNA (1.00) | LMNAF2TDP1ALDH1A1TSHR | |
| SCHEMBL10560176 | 0.70 | F2 (0.70) | LMNAF2TDP1ALDH1A1TSHR | |
| SCHEMBL29611759 | 0.70 | LMNA (0.70) | LMNAF2TDP1ALDH1A1TSHR | |
| SCHEMBL5244678 | 0.70 | F2 (0.70) | LMNAF2TDP1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435462-A1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | Pfizer Limited (GB) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010136940-A1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |