Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 4/20 | 0.37 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31374699 | 0.87 | AKR1C3 (0.41) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035563 | 0.87 | AKR1C3 (0.41) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035553 | 0.86 | AKR1C3 (0.42) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035626 | 0.83 | JAK2 (0.39) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL30683308 | 0.83 | JAK2 (0.39) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035554 | 0.78 | JAK2 (0.38) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL30683313 | 0.76 | TEAD1 (0.37) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035562 | 0.76 | JAK2 (0.39) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035687 | 0.76 | TEAD1 (0.37) | AKR1C3AKR1C2JAK2JAK1TYK2 | |
| SCHEMBL27035651 | 0.76 | JAK1 (0.42) | JAK2JAK1TYK2JAK3HSPA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020350-A1 | TEAD INHIBITORS AND METHODS OF USE | SPOROS BIODISCOVERY, INC. (US) | 2024-01-25 | — | — | WO | disclosed |