Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31370383 | 0.87 | KDM4E (0.43) | KDM4EPDE4AGPBAR1USP2SLCO1B1 | |
| SCHEMBL27068785 | 0.82 | GPBAR1 (0.34) | KDM4EGPBAR1MMP2MMP9MMP8 | |
| SCHEMBL26533468 | 0.76 | KDM4E (0.43) | KDM4EPDE4AGPBAR1USP2SLCO1B1 | |
| SCHEMBL25950269 | 0.76 | KDM4E (0.43) | KDM4EPDE4AGPBAR1USP2SLCO1B1 | |
| SCHEMBL27315841 | 0.76 | KDM4E (0.43) | KDM4EPDE4AGPBAR1USP2SLCO1B1 | |
| SCHEMBL27448156 | 0.74 | KDM4E (0.41) | KDM4EPDE4AGPBAR1MMP2MMP9 | |
| SCHEMBL27443608 | 0.74 | KDM4E (0.41) | KDM4EPDE4AGPBAR1MMP2MMP9 | |
| SCHEMBL27104564 | 0.73 | KDM4E (0.37) | KDM4EPDE4AGPBAR1USP2SLCO1B1 | |
| Meglumine SCHEMBL371153 | 0.71 | KDM4E (0.53) | KDM4EPDE4AUSP2SLCO1B1MMP2 | |
| Meglumine SCHEMBL11777 | 0.71 | KDM4E (0.53) | KDM4EPDE4AUSP2SLCO1B1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020164-A2 | GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF | FIREFLY BIO, INC. (US) | 2024-01-25 | — | — | WO | disclosed |