Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meglumine SCHEMBL11777 | 1.00 | KDM4E (0.53) | KDM4ESMN1; SMN2USP2SLCO1B1PDE4A | |
| SCHEMBL31038965 | 0.82 | USP2 (0.43) | KDM4EUSP2SLCO1B1PDE4AKMT2A | |
| SCHEMBL23388718 | 0.82 | USP2 (0.43) | KDM4EUSP2SLCO1B1PDE4AKMT2A | |
| SCHEMBL30721492 | 0.82 | USP2 (0.43) | KDM4EUSP2SLCO1B1PDE4AKMT2A | |
| SCHEMBL31370383 | 0.80 | KDM4E (0.43) | KDM4ESMN1; SMN2USP2SLCO1B1PDE4A | |
| SCHEMBL8139 | 0.80 | KMT2A (0.50) | KMT2AALOX15BLMPMP22MMP2 | |
| SCHEMBL154381 | 0.80 | KMT2A (0.50) | KMT2AALOX15BLMPMP22MMP2 | |
| SCHEMBL8140 | 0.80 | KMT2A (0.50) | KMT2AALOX15BLMPMP22MMP2 | |
| Hydrochloric Acid SCHEMBL22978412 | 0.78 | KMT2A (0.48) | KMT2AALOX15BLMPMP22MMP2 | |
| Hydrochloric Acid SCHEMBL23834101 | 0.78 | KMT2A (0.48) | KMT2AALOX15BLMPMP22MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015168135-A1 | NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-11-05 | — | — | WO | disclosed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |
| US-8106069-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2012-01-31 | — | — | US | disclosed |
| US-20120014918-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | ALMIRALL, S.A. (ES) | 2012-01-19 | — | — | US | disclosed |
| EP-2406225-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | Almirall S.A. (ES) | 2012-01-18 | — | — | EP | disclosed |
| WO-2011143587-A1 | NITRO FATTY ACIDS - NEUROPROTECTION AND/OR INHIBITION OF COGNITIVE DECLINE | NITROMEGA CORP. (US) | 2011-11-17 | — | — | WO | disclosed |
| EP-2376492-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-19 | — | — | EP | disclosed |
| US-8038984-B2 | Membrane-permeant peptide complexes for treatment of sepsis | WASHINGTON UNIVERSITY (US) | 2011-10-18 | — | — | US | disclosed |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2011-10-13 | — | — | US | disclosed |
| WO-2011092120-A1 | 6,7- DIHYDROIMIDAZO [1,5-A] PYRAZIN-8 (5H) - ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |
| US-20110190224-A1 | Non-Viral Delivery of Compounds to Mitochondria | PAYNE R MARK | 2011-08-04 | — | — | US | disclosed |
| US-20110183971-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-07-28 | — | — | US | disclosed |
| WO-2011072132-A1 | METHODS OF TREATING INFLAMMATORY CONDITIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011067145-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-09 | — | — | WO | disclosed |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2011-06-09 | — | — | US | disclosed |
| US-20110118278-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-19 | — | — | US | disclosed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |
| EP-2300436-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | Nerviano Medical Sciences S.r.l. (IT) | 2011-03-30 | — | — | EP | disclosed |
| US-7888508-B2 | 3-(carboxy or carbamoyl)-5-amino-1H-pyrrolo(2,3-b)pyridines; cancer, Alzheimer's disease, viral infections, autoimmune diseases and neurodegenerative disorders; chemical libraries of these compounds | PFIZER ITALIA S.R.L. (IT) | 2011-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183971-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MAP3K1, PDPK1, MAP3K15 | KDM4E 946/4885SMN1; SMN2 1587/4885USP2 3499/4885 |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | PDK1, PDPK1, CDK3 | KDM4E 998/4885SMN1; SMN2 834/4885USP2 3498/4885 |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K6, MAP3K3, MAP3K15 | KDM4E 652/4885SMN1; SMN2 1555/4885USP2 1029/4885 |
| US-20110118278-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | DMPK, DCK, MAP3K19 | KDM4E 623/4885SMN1; SMN2 4039/4885USP2 3597/4885 |
| US-20120014918-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | DHODH, DAO, ADH1B | KDM4E 3178/4885SMN1; SMN2 2107/4885USP2 2982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.