Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 19/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 18/20 | 0.98 |
| ▸ | CHRM4 | P08173 | 18/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 18/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 18/20 | 0.98 |
| ▸ | DRD2 | P14416 | 14/20 | 0.98 |
| ▸ | DRD4 | P21917 | 14/20 | 0.98 |
| ▸ | DRD3 | P35462 | 14/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.78 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.78 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30777193 | 0.93 | CHRM1 (0.89) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL22077888 | 0.93 | CHRM1 (0.89) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL29400334 | 0.88 | CHRM2 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4100746 | 0.88 | CHRM2 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL22032519 | 0.83 | CHRM1 (0.77) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL31402667 | 0.83 | CHRM1 (0.77) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL22077988 | 0.83 | CHRM1 (0.73) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL22032267 | 0.83 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL22032220 | 0.83 | CHRM2 (0.79) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL30777190 | 0.83 | CHRM2 (0.79) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891143-B1 | QUINOLINONE AND BENZOXAZINE DERIVATIVES AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS | HEPTARES THERAPEUTICS LTD (GB) | 2024-01-31 | — | — | EP | disclosed |