SCHEMBL29400334

SCHEMBL29400334

CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 19/20 1.00
CHRM4 P08173 19/20 1.00
CHRM5 P08912 19/20 1.00
CHRM1 P11229 19/20 1.00
CHRM3 P20309 19/20 1.00
DRD2 P14416 14/20 1.00
DRD4 P21917 14/20 1.00
DRD3 P35462 14/20 1.00
ADRB2 P07550 3/20 1.00
ADRB1 P08588 3/20 1.00
ADRA1D P25100 3/20 1.00
ADRA1A P35348 3/20 1.00
ADRA1B P35368 3/20 1.00
GRIN1 Q05586 1/20 0.58
GRIN2B Q13224 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4100746 1.00 CHRM2 (1.00) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL2149709 0.90 CHRM5 (0.81) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL27074530 0.88 CHRM1 (0.98) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL30777193 0.87 CHRM1 (0.89) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL22077888 0.87 CHRM1 (0.89) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4103777 0.86 CHRM1 (0.75) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4097774 0.86 CHRM1 (0.75) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4097069 0.85 CHRM1 (0.74) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4095226 0.85 CHRM1 (0.74) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4089899 0.85 CHRM1 (0.74) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024100285-A1 TREATMENT OF A COGNITIVE DISORDER WITH AN AGENT THAT INCREASES THE EXCITABILITY OF THE CLAUSTRUM UNIVERSITÉ DE GENÈVE (CH) 2024-05-16 WO claimed
US-20220347170-A1 Method of Reducing Brow Ache LENZ THERAPEUTICS OPERATIONS, INC. 2022-11-03 US claimed
WO-2022232205-A1 A METHOD OF REDUCING BROW ACHE LENZ THERAPEUTICS, INC. (US) 2022-11-03 WO claimed
EP-3310336-B1 OPHTHALMOLOGICAL COMPOSITION COMPRISING ACECLIDINE AND MANNITOL FOR USE IN THE TREATMENT OF PRESBYOPIA LENZ THERAPEUTICS OPERATIONS INC (US) 2026-05-20 EP disclosed
US-20260098245-A1 Differentiation Method KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) 2026-04-09 US disclosed
US-12590297-B2 Differentiation method KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) 2026-03-31 US disclosed
US-20260069533-A1 METHODS FOR THE TREATMENT OF PRESBYOPIA LENZ THERAPEUTICS OPERATIONS INC (US) 2026-03-12 US disclosed
US-20260055116-A1 SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS KARUNA THERAPEUTICS INC (US) 2026-02-26 US disclosed
US-12533347-B2 Compositions and methods for storage stable ophthalmic drugs LENZ THERAPEUTICS OPERATIONS, INC. (US) 2026-01-27 US disclosed
US-20250352529-A1 COMBINED USE OF M1 MUSCARINIC RECEPTOR AGONISTS AND M3 MUSCARINIC RECEPTOR ANTAGONISTS TO TREAT CANCER US GOV VETERANS AFFAIRS (US) 2025-11-20 US disclosed
EP-4634193-A1 SUBSTITUTED DIHYDROPYRROLO[3, 4-D]PYRIMIDINE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS Karuna Therapeutics, Inc. (US) 2025-10-22 EP disclosed
US-20220218874-A1 COMPOSITIONS AND METHODS OF MODULATING ENDOCHONDRAL OSSIFICATION AND BONE FORMATION UNIV CASE WESTERN RESERVE (US) 2022-07-14 US disclosed
US-11344538-B2 Methods for the treatment of myopia LENZ THERAPEUTICS, INC. (US) 2022-05-31 US disclosed
US-20220125779-A1 Compositions and Methods for Treating Traumatic Brain Injury NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-04-28 US disclosed
WO-2022081204-A1 COMPOSITIONS AND METHODS FOR STORAGE STABLE OPHTHALMIC DRUGS PRESBYOPIA THERAPIES, INC. (US) 2022-04-21 WO disclosed
US-20220105090-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS LENZ THERAPEUTICS, INC. 2022-04-07 US disclosed
US-11273150-B2 Compositions and methods for the treatment of presbyopia LENZ THERAPEUTICS, INC. (US) 2022-03-15 US disclosed
US-11274158-B2 Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2022-03-15 US disclosed
US-20220054462-A1 SALIVARY GLAND REGENERATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-02-24 US disclosed
US-20220031608-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA LENZ THERAPEUTICS OPERATIONS, INC. 2022-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260069533-A1 METHODS FOR THE TREATMENT OF PRESBYOPIA CHRM2, ADRB2, CHRM3 CHRM2 1/4885CHRM4 4/4885CHRM5 7/4885
US-20260098245-A1 Differentiation Method GAPDH, ALPG, PYGL CHRM2 3365/4885CHRM4 2430/4885CHRM5 3149/4885
US-12533347-B2 Compositions and methods for storage stable ophthalmic drugs PDE6C, PDE6A, PDE6B CHRM2 143/4885CHRM4 201/4885CHRM5 214/4885
US-12590297-B2 Differentiation method WNT3A, SFRP1, WNT1 CHRM2 3473/4885CHRM4 3391/4885CHRM5 3991/4885
US-20260055116-A1 SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS CHRM3, CHRM2, CHRM1 CHRM2 2/4885CHRM4 6/4885CHRM5 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.