Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707625 | 0.88 | CTNNB1 (0.59) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL28634306 | 0.81 | POLB (0.61) | CTNNB1HTTALDH1A1KDM4EPYGL | |
| SCHEMBL11773037 | 0.81 | PYGL (0.54) | HTTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2705224 | 0.81 | HTT (0.47) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL2355280 | 0.79 | CTNNB1 (0.58) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL28411450 | 0.79 | CTNNB1 (0.66) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL742799 | 0.78 | CTNNB1 (0.53) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL30975119 | 0.78 | CTNNB1 (0.53) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL8408145 | 0.78 | CTNNB1 (0.61) | CTNNB1HTTALDH1A1KDM4EHPGD | |
| SCHEMBL1892492 | 0.78 | CTNNB1 (0.77) | CTNNB1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435462-A1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | Pfizer Limited (GB) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010136940-A1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |