Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867625 | 0.94 | CA2 (0.41) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1864944 | 0.87 | CA2 (0.44) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1870339 | 0.81 | CA2 (0.43) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1867950 | 0.81 | CA2 (0.43) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1867951 | 0.81 | CA2 (0.43) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1700490 | 0.81 | CA2 (0.43) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1867014 | 0.81 | CA2 (0.43) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1700492 | 0.81 | CA2 (0.43) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1700199 | 0.80 | HTT (0.47) | VCAM1MAPTNPSR1CA12CA1 | |
| SCHEMBL1867757 | 0.79 | CA2 (0.46) | VCAM1MAPTNPSR1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |