Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Fluorescein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL5415734 | 0.95 | FTO (0.65) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL23211051 | 0.91 | FTO (0.58) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL20396201 | 0.84 | FTO (0.60) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL28075803 | 0.84 | FTO (0.82) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL4807011 | 0.84 | FTO (0.82) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL1290366 | 0.83 | FTO (0.81) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL5664541 | 0.83 | FTO (0.85) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL16545 | 0.83 | FTO (0.85) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL27822133 | 0.83 | FTO (0.85) | FTOMAPTMEN1KMT2AHTT | |
| Fluorescein SCHEMBL5409874 | 0.82 | FTO (0.58) | FTOMAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106834429-B | Biomarker for confirming exposure of fine dust of 2.5 μm or less and confirmation method using the same | 韩国科学技术研究院 | 2021-01-22 | — | — | CN | claimed |
| US-20240043508-A1 | ANTIBODY BINDING SPECIFICALLY TO SARS-COV-2 S PROTEIN OR ANTIGEN-BINDING FRAGMENT THEREOF, BISPECIFIC ANTIBODY, AND USES THEREOF | KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION (KR) | 2024-02-08 | — | — | US | disclosed |
| CN-106834429-B | Biomarker for confirming exposure of fine dust of 2.5 μm or less and confirmation method using the same | 韩国科学技术研究院 | 2021-01-22 | — | — | CN | disclosed |