Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27086356 | 0.84 | GRM2 (0.42) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL30004086 | 0.84 | GRM2 (0.42) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL32686477 | 0.81 | CLK1 (0.35) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL25413193 | 0.81 | CDK5 (0.49) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL30598973 | 0.81 | HTR2A (0.38) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL25186469 | 0.81 | HTR2A (0.38) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL27085824 | 0.78 | MEN1 (0.40) | PIK3CDPIK3CBPIK3CACLK4PIM1 | |
| SCHEMBL32686542 | 0.77 | PIK3CD (0.36) | GRM2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL18863211 | 0.76 | GRM2 (0.50) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL27086002 | 0.75 | GRM2 (0.40) | GRM2PIK3CDPIK3CBPIK3CACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081311-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2024-04-18 | — | — | WO | disclosed |
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022217276-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-10-13 | — | — | WO | disclosed |