Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27086356 | 1.00 | GRM2 (0.42) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL27085777 | 0.84 | GRM2 (0.41) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL30598935 | 0.81 | CDK5 (0.50) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL32686478 | 0.81 | ALDH1A1 (0.37) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL25415363 | 0.81 | CDK5 (0.50) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL21200740 | 0.80 | GRM2 (0.35) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL30605858 | 0.80 | GRM2 (0.38) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL30598890 | 0.80 | GRM2 (0.35) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL18863211 | 0.77 | GRM2 (0.50) | GRM2PIK3CDPIK3CBPIK3CACLK4 | |
| SCHEMBL29920437 | 0.77 | ALDH1A1 (0.42) | PIK3CDPIK3CBPIK3CAPIM1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709718-A1 | 6-SUBSTITUTED-3-PHENYL-ISOINDOLIN-1-ONES AS CBL-B INHIBITORS SELECTIVE OVER C-CBL | Genentech Inc. (US) | 2026-03-18 | — | — | EP | disclosed |
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |