Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31159024 | 0.78 | CLK4 (0.58) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL17141660 | 0.76 | CLK4 (0.46) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL27085985 | 0.75 | GRM2 (0.41) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL27086006 | 0.74 | GRM2 (0.47) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL27086002 | 0.74 | GRM2 (0.40) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL18863211 | 0.71 | GRM2 (0.50) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL24147834 | 0.70 | CLK4 (0.53) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL30013219 | 0.70 | CLK4 (0.46) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL25411512 | 0.70 | CLK4 (0.53) | CLK4PIM1ROCK1CDK5DYRK1A | |
| SCHEMBL30068832 | 0.70 | PIM1 (0.53) | CLK4PIM1ROCK1CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022217276-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-10-13 | — | — | WO | disclosed |