Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.63 |
| ▸ | INSR | P06213 | 3/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | NPM1 | P06748 | 1/20 | 0.59 |
| ▸ | FES | P07332 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27091505 | 0.90 | FGFR3 (0.62) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL30741323 | 0.90 | FGFR3 (0.62) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL26906516 | 0.89 | EGFR (0.80) | EGFRINSRIGF1RALK | |
| SCHEMBL27091352 | 0.85 | EGFR (0.62) | EGFRINSRIGF1RALKPTK2 | |
| SCHEMBL30741324 | 0.85 | EGFR (0.62) | EGFRINSRIGF1RALKPTK2 | |
| SCHEMBL22595710 | 0.84 | EGFR (0.59) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL26906874 | 0.83 | INSR (0.62) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL26906637 | 0.83 | EGFR (0.82) | EGFRINSRIGF1RALK | |
| SCHEMBL26906854 | 0.83 | INSR (0.62) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL26906853 | 0.82 | EGFR (0.71) | EGFRINSRIGF1RALKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240051940-A1 | SULFONAMIDES WITH EGFR INHIBITION ACTIVITIES AND THEIR USE THEREOF | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-02-15 | — | — | US | claimed |
| US-20240051940-A1 | SULFONAMIDES WITH EGFR INHIBITION ACTIVITIES AND THEIR USE THEREOF | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-02-15 | — | — | US | disclosed |
| WO-2022170164-A1 | SULFONAMIDES WITH EGFR INHIBITION ACTIVITIES AND THEIR USE THEREOF | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240051940-A1 | SULFONAMIDES WITH EGFR INHIBITION ACTIVITIES AND THEIR USE THEREOF | EGFR, ERBB2, ERBB4 | EGFR 1/4885INSR 1065/4885IGF1R 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.