Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.51 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185372 | 0.95 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2AMLLT3 | |
| SCHEMBL181956 | 0.86 | MEN1 (0.73) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL182130 | 0.85 | NPC1 (0.55) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL182206 | 0.85 | NPC1 (0.65) | MEN1NPC1RAB9AKMT2AMLLT3 | |
| SCHEMBL18289064 | 0.84 | GAA (0.54) | MEN1NPC1RAB9AKMT2AMLLT3 | |
| SCHEMBL181944 | 0.84 | MEN1 (0.63) | MEN1NPC1RAB9AKMT2AEGLN1 | |
| SCHEMBL14403364 | 0.84 | MEN1 (0.66) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL7510493 | 0.83 | ALKBH2 (0.71) | MEN1NPC1RAB9AKMT2AMLLT3 | |
| SCHEMBL16872782 | 0.83 | GAA (0.53) | MEN1NPC1RAB9AKMT2AMLLT3 | |
| SCHEMBL182242 | 0.83 | KMT2A (0.69) | MEN1NPC1RAB9AKMT2AHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387995-A1 | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith | PTC Therapeutics, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |