SCHEMBL27092925

SCHEMBL27092925

Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](C[Se]CC[C@H](N)C(=O)O)O1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NNMT P40261 3/20 0.57
DOT1L Q8TEK3 5/20 0.56
CARM1 Q86X55 4/20 0.56
EHMT2 Q96KQ7 4/20 0.56
NSD2 O96028 3/20 0.56
SETD7 Q8WTS6 3/20 0.56
PCMT1 P22061 2/20 0.56
TRDMT1 O14717 2/20 0.56
PRMT5 O14744 2/20 0.56
INMT O95050 2/20 0.56
METTL3 Q86U44 2/20 0.56
PRMT1 Q99873 2/20 0.56
EHMT1 Q9H9B1 2/20 0.56
METTL14 Q9HCE5 2/20 0.56
RNMT O43148 1/20 0.56
TPMT P51580 1/20 0.56
NSD1 Q96L73 1/20 0.56
SETD2 Q9BYW2 1/20 0.56
NSD3 Q9BZ95 1/20 0.56
FASN P49327 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27092933 1.00 NNMT (0.57) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL13978098 0.86 DOT1L (0.72) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL27092984 0.85 DOT1L (0.73) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL20097045 0.85 DOT1L (0.73) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL17079892 0.84 NNMT (0.76) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL17079889 0.84 NNMT (0.76) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL28157647 0.84 NNMT (0.76) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL27092943 0.84 NNMT (0.76) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL27092948 0.84 NNMT (0.76) NNMTDOT1LCARM1EHMT2NSD2
SCHEMBL22276216 0.82 NNMT (0.54) NNMTDOT1LCARM1EHMT2NSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4324928-A1 SYNTHETIC REAGENTS FOR ENZYME-CATALYSED ALKYLATION Universität Basel (CH) 2024-02-21 EP claimed
EP-4324928-A1 SYNTHETIC REAGENTS FOR ENZYME-CATALYSED ALKYLATION Universität Basel (CH) 2024-02-21 EP disclosed