Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27099909 | 1.00 | GFER (0.47) | GFERSMPD3ALDH1A1MEN1HPGD | |
| SCHEMBL26633305 | 0.95 | SMPD3 (0.50) | GFERSMPD3ALDH1A1MEN1HPGD | |
| SCHEMBL26633302 | 0.95 | SMPD3 (0.50) | GFERSMPD3ALDH1A1MEN1HPGD | |
| SCHEMBL26633307 | 0.95 | SMPD3 (0.50) | GFERSMPD3ALDH1A1MEN1HPGD | |
| SCHEMBL24092755 | 0.79 | ALDH1A1 (0.45) | GFERSMPD3ALDH1A1MEN1HPGD | |
| SCHEMBL26739781 | 0.79 | CHRM4 (0.45) | SMPD3CHRM4JAK3HTTLMNA | |
| SCHEMBL16255265 | 0.78 | CNR2 (0.50) | ALDH1A1CHRM4LMNASMN1; SMN2KDM4E | |
| SCHEMBL16254909 | 0.78 | ALDH1A1 (0.46) | SMPD3ALDH1A1CHRM4JAK3HTT | |
| SCHEMBL27583894 | 0.78 | GRM5 (0.37) | GFERALDH1A1KMT2AMAPT | |
| SCHEMBL17696407 | 0.78 | SMPD3 (0.45) | SMPD3CHRM4JAK3HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |