Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29739580 | 1.00 | MAPT (0.61) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL26633342 | 0.96 | MAPT (0.63) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL26633289 | 0.96 | MAPT (0.63) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL26633283 | 0.96 | MAPT (0.63) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL10898231 | 0.80 | MAPT (0.58) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL15141694 | 0.79 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL30206059 | 0.79 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL15141990 | 0.79 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL15141692 | 0.79 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAALOX12NPSR1 | |
| SCHEMBL2681979 | 0.79 | MAPT (0.55) | MAPTALDH1A1LMNAALOX12NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |