Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27093852 | 1.00 | PTPN1 (0.52) | PTPN1TLR2MDM4TP53MDM2 | |
| SCHEMBL27093790 | 0.93 | TLR2 (0.49) | PTPN1TLR2MDM4TP53MDM2 | |
| SCHEMBL27093787 | 0.93 | TLR2 (0.49) | PTPN1TLR2MDM4TP53MDM2 | |
| SCHEMBL19615686 | 0.91 | PTPN1 (0.49) | PTPN1TLR2 | |
| SCHEMBL29938622 | 0.91 | PTPN1 (0.49) | PTPN1TLR2CASP3 | |
| SCHEMBL18452568 | 0.91 | PTPN1 (0.49) | PTPN1TLR2CASP3 | |
| SCHEMBL18452611 | 0.91 | PTPN1 (0.49) | PTPN1TLR2 | |
| SCHEMBL18476829 | 0.91 | PTPN1 (0.49) | PTPN1TLR2 | |
| SCHEMBL29938558 | 0.91 | MDM4 (0.52) | TLR2MDM4TP53MDM2CASP3 | |
| SCHEMBL22347004 | 0.91 | MDM4 (0.52) | TLR2MDM4TP53MDM2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322961-A1 | DENDRIMER-GLUTAMINE ANTAGONIST CONJUGATES AND METHODS OF USE THEREOF | The Johns Hopkins University (US) | 2024-02-21 | — | — | EP | disclosed |
| CN-112920092-A | Prodrugs of glutamine analogs | 约翰霍普金斯大学 | 2021-06-08 | — | — | CN | disclosed |