Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 12/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30838056 | 0.99 | PRKCQ (0.49) | PRKCQJAK1HRH4JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL30838083 | 0.92 | PRKCQ (0.49) | PRKCQJAK1HRH4JAK2JAK3 | |
| SCHEMBL24288100 | 0.84 | PRKCQ (0.47) | PRKCQHRH4CCNE1CDK2 | |
| SCHEMBL24288092 | 0.83 | JAK1 (0.44) | JAK1HRH4JAK2JAK3CCNE1 | |
| SCHEMBL24288237 | 0.83 | PRKCQ (0.48) | PRKCQHRH4 | |
| Hydrochloric Acid SCHEMBL30838074 | 0.83 | JAK1 (0.44) | JAK1HRH4JAK2JAK3CCNE1 | |
| Hydrochloric Acid SCHEMBL30838055 | 0.81 | PRKCQ (0.40) | PRKCQJAK1JAK2JAK3ADORA2A | |
| Hydrochloric Acid SCHEMBL30838021 | 0.78 | JAK1 (0.39) | JAK1HRH4JAK2JAK3CCNE1 | |
| SCHEMBL24288090 | 0.77 | HRH4 (0.45) | PRKCQHRH4 | |
| SCHEMBL24288146 | 0.76 | HRH4 (0.42) | JAK1HRH4JAK2JAK3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240059677-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR | CEREVANCE LTD (GB) | 2024-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240059677-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR | CHRNA6, CHRM2, CHRNA1 | PRKCQ 2066/4885JAK1 3292/4885HRH4 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.