Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.54 |
| ▸ | THRA | P10827 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | UBE2M | P61081 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25400144 | 1.00 | POLB (0.59) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL27101578 | 0.93 | EPHX1 (0.55) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL25402876 | 0.93 | EPHX1 (0.55) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL26553774 | 0.88 | POLB (0.56) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL26553987 | 0.85 | PTPN2 (0.61) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL25399287 | 0.84 | EPHX1 (0.49) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL25399406 | 0.84 | EPHX1 (0.49) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL27100530 | 0.84 | EPHX1 (0.49) | POLBS1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL25398309 | 0.82 | EPHX2 (0.67) | S1PR1EPHX1EPHX2SPHK1LMNA | |
| SCHEMBL26553772 | 0.82 | F10 (0.53) | POLBEPHX1EPHX2SPHK1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331683-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230331683-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | SPNS2, SPCS2, SMN1; SMN2 | POLB 2637/4885S1PR1 561/4885S1PR3 676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.