Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2710840 | 1.00 | PTPN11 (0.51) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL7089930 | 1.00 | PTPN11 (0.51) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL7089886 | 0.94 | TP53 (0.46) | PTPN11S1PR3PTPN1PTPN6ALDH1A1 | |
| SCHEMBL23748675 | 0.89 | PLA2G2A (0.50) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL9413367 | 0.83 | TSHR (0.38) | PTPN11ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL668981 | 0.82 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL35210991 | 0.82 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL4462194 | 0.82 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL10539639 | 0.82 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL16836639 | 0.82 | PTPN11 (0.60) | PTPN11S1PR3PTPN1PTPN6PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980925-B2 | Antimicrobial amphiphiles and methods for their use | JAMES MADISON INNOVATIONS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140148487-A1 | ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE | James Madison Innovations, Inc, (US) | 2014-05-29 | — | — | US | disclosed |
| WO-2012054695-A1 | NTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE | JAMES MADISON INNOVATIONS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148487-A1 | ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE | ANXA5, ANXA4, ANXA6 | PTPN11 4424/4885S1PR3 963/4885PTPN1 4272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.