Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514381 | 0.80 | GRM1 (0.47) | GRM1CYP3A4CYP2D6KDM4ERECQL | |
| SCHEMBL12835720 | 0.80 | GRM1 (0.47) | GRM1CYP3A4CYP2D6KDM4ERECQL | |
| SCHEMBL2084217 | 0.79 | ALDH1A1 (0.51) | GRM1CYP3A4CYP2D6PIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL1514298 | 0.78 | GRM1 (0.46) | GRM1CYP3A4CYP2D6KDM4ERECQL | |
| SCHEMBL27960788 | 0.74 | GRM1 (0.49) | GRM1CYP3A4CYP2D6KCNMA1PARP1 | |
| SCHEMBL28798382 | 0.74 | KDM4E (0.39) | CYP3A4CYP2D6USP30KDM4EALDH1A1 | |
| SCHEMBL30307674 | 0.74 | KDM4E (0.47) | GRM1CYP3A4CYP2D6KCNMA1PARP1 | |
| SCHEMBL21722525 | 0.74 | GRM1 (0.45) | GRM1CYP3A4CYP2D6KCNMA1PARP1 | |
| SCHEMBL21722473 | 0.74 | KDM4E (0.47) | GRM1CYP3A4CYP2D6KCNMA1PARP1 | |
| SCHEMBL30556673 | 0.73 | GRM1 (0.60) | GRM1CYP3A4CYP2D6KCNMA1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |