Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27115447 | 0.88 | CLK1 (0.57) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL27113280 | 0.84 | KIT (0.47) | KITCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27144345 | 0.79 | SYK (0.49) | KITCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27115340 | 0.79 | CDK2 (0.53) | CDK2SRCCDK4ABL1EGFR | |
| SCHEMBL27118927 | 0.76 | CDK2 (0.50) | KITCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27151879 | 0.76 | GSK3B (0.53) | KITCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27118928 | 0.76 | ABL1 (0.61) | DYRK1ASMG1CDK2SYKSRC | |
| SCHEMBL27115203 | 0.76 | ABL1 (0.61) | MTORSMG1CDK2CDK4CDK1 | |
| SCHEMBL27115201 | 0.73 | ABL1 (0.45) | CLK1DYRK1ACLK4MTORSMG1 | |
| SCHEMBL27111699 | 0.73 | CLK1 (0.62) | CLK1CLK2DYRK1ACLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |