Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.49 |
| ▸ | SRC | P12931 | 8/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | CLK1 | P49759 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | BCR | P11274 | 3/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116471 | 0.84 | CLK1 (0.66) | SRCCDK2CLK1CLK2DYRK1A | |
| SCHEMBL27151879 | 0.84 | GSK3B (0.53) | SYKSRCZAP70CDK2CLK1 | |
| SCHEMBL27115272 | 0.84 | PLK1 (0.47) | SYKSRCCDK2CLK1CLK2 | |
| SCHEMBL27115678 | 0.81 | PLK1 (0.49) | SRCZAP70CLK1CLK2DYRK1A | |
| SCHEMBL27113280 | 0.80 | KIT (0.47) | SYKSRCZAP70CDK2CLK1 | |
| SCHEMBL27144622 | 0.80 | ABL1 (0.62) | SRCZAP70PLK1ABL1BCR | |
| SCHEMBL27114602 | 0.79 | KIT (0.45) | SYKSRCZAP70CDK2CLK1 | |
| SCHEMBL27146831 | 0.79 | SYK (0.50) | SYKSRCZAP70CDK2CLK1 | |
| SCHEMBL27154547 | 0.79 | SYK (0.50) | SYKSRCCLK1CLK2DYRK1A | |
| SCHEMBL27115894 | 0.78 | CAMK2D (0.60) | SYKSRCCLK1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |