Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | IDH2 | P48735 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116471 | 0.86 | CLK1 (0.66) | AURKAKDM4ECLK1CLK2DYRK1A | |
| SCHEMBL27110252 | 0.81 | CLK1 (0.66) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL30847409 | 0.81 | CLK1 (0.66) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL5732656 | 0.81 | AURKA (0.66) | AURKAKDM4ECLK1CLK2DYRK1A | |
| SCHEMBL27116136 | 0.81 | CLK1 (0.62) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27115596 | 0.80 | SYK (0.65) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL15533886 | 0.79 | CLK1 (0.67) | AURKAKDM4ECLK1CLK2DYRK1A | |
| SCHEMBL4901590 | 0.78 | ABL1 (0.67) | AURKAKDM4ECLK1CLK2DYRK1A | |
| SCHEMBL4737084 | 0.78 | SYK (0.62) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL13924473 | 0.78 | SYK (0.74) | AURKACLK1CLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |