Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.59 |
| ▸ | IDH2 | P48735 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 5/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469928 | 0.83 | ABL1 (0.64) | ABL1BCRPRKCACLK2DYRK1A | |
| SCHEMBL4901590 | 0.82 | ABL1 (0.67) | AURKAABL1BCRPRKCACLK1 | |
| SCHEMBL6663767 | 0.82 | AURKA (0.72) | AURKAIDH2KDM4E | |
| SCHEMBL31501743 | 0.82 | AURKA (0.72) | AURKAIDH2KDM4E | |
| SCHEMBL25337941 | 0.81 | AURKA (0.62) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL30554562 | 0.81 | AURKA (0.62) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27119202 | 0.81 | AURKA (0.60) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL7470857 | 0.80 | ABL1 (0.63) | AURKAABL1BCRPRKCASYK | |
| SCHEMBL4903508 | 0.80 | ABL1 (0.67) | ABL1BCRPRKCASYKCDK2 | |
| SCHEMBL5734023 | 0.80 | ABL1 (0.64) | ABL1BCRPRKCASYKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672042-B1 | PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-5705502-A | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof | NOVARTIS CORPORATION (US) | 1998-01-06 | — | — | US | disclosed |