Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 3/20 | 0.32 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26965364 | 1.00 | CNR1 (0.32) | CNR1ALDH1A1LMNAMMEGRN | |
| SCHEMBL4788962 | 0.82 | NPC1 (0.37) | LMNA | |
| SCHEMBL13210035 | 0.72 | — | — | |
| SCHEMBL27128098 | 0.71 | PLA2G10 (0.33) | ALDH1A1LMNAFOLH1MMEL1 | |
| SCHEMBL26965342 | 0.71 | LMNA (0.43) | CNR1LMNAMME | |
| SCHEMBL27127864 | 0.71 | LMNA (0.43) | CNR1LMNAMME | |
| SCHEMBL26965372 | 0.71 | PLA2G10 (0.33) | ALDH1A1LMNAFOLH1MMEL1 | |
| SCHEMBL24387617 | 0.70 | SCN10A (0.39) | ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL27120118 | 0.69 | SCN10A (0.38) | ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL26965329 | 0.69 | SCN10A (0.38) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230406860-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. | 2023-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406860-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | KRAS, NRAS, HRAS | CNR1 3281/4885ALDH1A1 1457/4885LMNA 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.