Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | DDX6 | P26196 | 1/20 | 0.36 |
| ▸ | CSK | P41240 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27122135 | 0.89 | PIK3CA (0.47) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL25358982 | 0.84 | PIK3CA (0.60) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL27153046 | 0.80 | CHRM3 (0.43) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL27122134 | 0.79 | PIK3CA (0.43) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL27116505 | 0.78 | PIK3CA (0.78) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL27136855 | 0.74 | PIK3CA (0.62) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL27122133 | 0.74 | PIK3CA (0.40) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL27121826 | 0.73 | PIK3CA (0.61) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL25364344 | 0.72 | PIK3CA (0.63) | PIK3CAAKT1AKT2AKT3PRKDC | |
| SCHEMBL25358740 | 0.72 | PIK3CA (0.60) | PIK3CAAKT1AKT2AKT3PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260078120-A1 | SUBSTITUTED PYRIDOPYRIMIDINONES | Mirati Therapeutics, Inc. (US) | 2026-03-19 | — | — | US | disclosed |
| EP-4577544-A1 | SUBSTITUTED PYRIDOPYRIMIDINONES | Mirati Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044769-A1 | SUBSTITUTED PYRIDOPYRIMIDINONES | Mirati Therapeutics, Inc. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044769-A1 | SUBSTITUTED PYRIDOPYRIMIDINONES | Mirati Therapeutics, Inc. (US) | 2024-02-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260078120-A1 | SUBSTITUTED PYRIDOPYRIMIDINONES | CBR1, CBR3, CNR1 | PIK3CA 2749/4885AKT1 2105/4885AKT2 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.