Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.32 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.31 |
| ▸ | GPR65 | Q8IYL9 | 2/20 | 0.31 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712714 | 0.83 | KDM4E (0.47) | JAK2JAK3UBE2MDCUN1D1 | |
| SCHEMBL14928348 | 0.76 | KHK (0.41) | KHKACHEPOLBJAK2JAK3 | |
| SCHEMBL16164779 | 0.75 | KHK (0.35) | KHKACHEPOLBBCHE | |
| SCHEMBL16164780 | 0.75 | KHK (0.35) | KHKACHEPOLBBCHE | |
| SCHEMBL14928687 | 0.75 | SOS1 (0.43) | KHKACHEPOLBJAK2JAK3 | |
| SCHEMBL16164181 | 0.75 | KHK (0.40) | KHKPOLB | |
| SCHEMBL2712638 | 0.74 | KHK (0.45) | KHK | |
| SCHEMBL2712632 | 0.74 | KHK (0.45) | KHK | |
| SCHEMBL14908857 | 0.74 | KHK (0.36) | KHK | |
| SCHEMBL14909075 | 0.74 | KHK (0.34) | KHKACHEJAK2JAK3BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |