Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714445 | 0.88 | GRM5 (0.76) | GRM5ALDH1A1HTTPOLBCYP11B2 | |
| SCHEMBL2715440 | 0.85 | GRM5 (0.67) | GRM5ALDH1A1HTTPOLB | |
| SCHEMBL2715105 | 0.82 | GRM5 (0.79) | GRM5ALDH1A1HTTPOLBKDM4E | |
| SCHEMBL2716611 | 0.81 | GRM5 (0.77) | GRM5ALDH1A1HTT | |
| SCHEMBL2717432 | 0.81 | GRM5 (0.65) | GRM5ALDH1A1HTTPOLBCYP11B2 | |
| SCHEMBL2718522 | 0.81 | GRM5 (0.61) | GRM5ALDH1A1HTTPOLBCYP11B2 | |
| SCHEMBL2716824 | 0.81 | GRM5 (1.00) | GRM5ALDH1A1HTT | |
| SCHEMBL2714770 | 0.79 | GRM5 (0.66) | GRM5ALDH1A1HTTPOLBKDM4E | |
| SCHEMBL2714660 | 0.79 | GRM5 (0.77) | GRM5ALDH1A1HTTCYP11B2 | |
| SCHEMBL2713551 | 0.78 | GRM5 (0.60) | GRM5ALDH1A1HTTPOLBCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052451-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-26 | — | — | WO | claimed |
| WO-2012052451-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-26 | — | — | WO | disclosed |