Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 8/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26696289 | 1.00 | NAMPT (0.38) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL26728704 | 1.00 | NAMPT (0.38) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL30662846 | 0.92 | NAMPT (0.39) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL26726272 | 0.92 | NAMPT (0.39) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL26705566 | 0.92 | NAMPT (0.39) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL27152357 | 0.92 | NAMPT (0.39) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL26696288 | 0.83 | NAMPT (0.41) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL25472502 | 0.83 | NAMPT (0.37) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL29898019 | 0.83 | NAMPT (0.37) | NAMPTADORA2BADORA2AADORA1TACR1 | |
| SCHEMBL26696291 | 0.78 | NAMPT (0.38) | NAMPTTACR1TGFBR1RORCUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260132133-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC (US) | 2026-05-14 | — | — | US | disclosed |
| US-12195465-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2025-01-14 | — | — | US | disclosed |
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | HRAS, KRAS, TP53 | NAMPT 1597/4885ADORA2B 4762/4885ADORA2A 4162/4885 |
| US-20260132133-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KRAS, HRAS, BCL6 | NAMPT 4853/4885ADORA2B 3284/4885ADORA2A 3803/4885 |
| US-12195465-B2 | Macrocyclic heterocycles and uses thereof | HRAS, KRAS, TP53 | NAMPT 1597/4885ADORA2B 4762/4885ADORA2A 4162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.