Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.55 |
| ▸ | AKT1 | P31749 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ASPH | Q12797 | 3/20 | 0.53 |
| ▸ | RIOX2 | Q8IUF8 | 3/20 | 0.53 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | STAT6 | P42226 | 4/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480282 | 0.88 | JAK3 (0.67) | RPS6KB1AKT1KDM4EASPHRIOX2 | |
| SCHEMBL2482471 | 0.80 | RPS6KB1 (0.60) | RPS6KB1AKT1JAK3IRAK4JAK2 | |
| SCHEMBL4409419 | 0.79 | KDM4E (0.60) | KDM4EASPHRIOX2KDM8JAK3 | |
| SCHEMBL913752 | 0.79 | CDK5 (0.62) | RPS6KB1AKT1KDM4EJAK3IRAK4 | |
| SCHEMBL12456033 | 0.79 | RPS6KB1 (0.54) | RPS6KB1AKT1JAK3IRAK4JAK2 | |
| SCHEMBL12280479 | 0.78 | RPS6KB1 (0.42) | RPS6KB1AKT1JAK3IRAK4JAK2 | |
| SCHEMBL29206798 | 0.78 | PKM (0.47) | RPS6KB1AKT1KDM4EASPHRIOX2 | |
| SCHEMBL2474877 | 0.78 | CD38 (0.54) | RPS6KB1JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2476348 | 0.78 | JAK3 (0.52) | RPS6KB1AKT1JAK3IRAK4JAK2 | |
| SCHEMBL2475770 | 0.78 | CDC7 (0.58) | RPS6KB1AKT1JAK3IRAK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |