Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 5/20 | 0.64 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.55 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HRH2 | P25021 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307243 | 1.00 | SCN4A (0.64) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL307244 | 1.00 | SCN4A (0.64) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL7939917 | 0.86 | DRD3 (0.56) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL29145448 | 0.86 | SCN4A (0.49) | SCN4ASCN3ASCN9ASCN5A | |
| SCHEMBL28912415 | 0.86 | SCN4A (0.49) | SCN4ASCN3ASCN9ASCN5A | |
| SCHEMBL15738520 | 0.86 | SCN4A (0.49) | SCN4ASCN3ASCN9ASCN5A | |
| SCHEMBL28912414 | 0.86 | SCN4A (0.49) | SCN4ASCN3ASCN9ASCN5A | |
| SCHEMBL14146257 | 0.85 | SCN4A (0.48) | SCN4ASCN3ASCN9ASCN5A | |
| SCHEMBL21552301 | 0.84 | NPC1 (0.49) | SCN4A | |
| SCHEMBL28912404 | 0.84 | SCN4A (0.48) | SCN4ASCN3ASCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574191-B | Isoxazole heterocyclic compound and application thereof | 南京圣和药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112574191-A | Isoxazole heterocyclic compound and application thereof | 南京圣和药业股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| EP-2630144-B1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-09-07 | — | — | EP | disclosed |
| US-9000154-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| EP-2630144-A1 | RHO KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2013-08-28 | — | — | EP | disclosed |
| US-20120270868-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-25 | — | — | US | disclosed |
| WO-2012054367-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270868-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | SCN4A 4051/4885SCN3A 3302/4885SCN9A 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.