Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DKK1 | O94907 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27154223 | 0.83 | DYRK1A (0.48) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL10973666 | 0.82 | GSK3B (0.55) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL27116290 | 0.81 | DYRK1A (0.47) | DYRK1AGSK3BCDK2PTGS1PTGS2 | |
| SCHEMBL27119298 | 0.78 | DYRK1A (0.47) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL27116293 | 0.78 | DYRK1A (0.49) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL10019585 | 0.78 | DYRK1A (0.49) | DYRK1AGSK3BCDK2PTGS1PTGS2 | |
| SCHEMBL10973799 | 0.78 | GSK3B (0.51) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL10019584 | 0.77 | DYRK1A (0.48) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL10972910 | 0.76 | NPC1 (0.51) | DYRK1AGSK3BCDK2MEN1KMT2A | |
| SCHEMBL27116235 | 0.72 | KDM4E (0.50) | DYRK1ACDK2MEN1KMT2ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |